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“In studies with mice and rats, researchers have found that a chemical messenger called NAPE is made in the small intestine after the animals ate a greasy meal. After eating, NAPE � N-acylphosphatidylethanolamine, a mouthful in itself -- enters the blood and travels to the brain, where it quashes hunger signals. Rats treated with extra NAPE for five days ate less and lost weight, hinting that studying NAPE could help researchers design better appetite suppressants or obesity drugs.” source...